Liang R, Chan W P, Kwong Y L, Chan A C, Xu W S, Au W Y, Srivastava G, Ho F C
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Br J Haematol. 1997 Dec;99(3):668-70. doi: 10.1046/j.1365-2141.1997.4443254.x.
The presence of the bcl-6 gene hypermutation was studied in 40 Hong Kong Chinese patients with diffuse large B-cell lymphoma. The primary sites of involvement were nodal in 18 cases and gastric in 22. Hypermutations at the E1.11 segment of bcl-6 gene were detectable in 16/22 (73%) primary gastric and 4/18 (22%) primary nodal lymphoma (P<0.01). Three of the 22 cases of primary gastric but none of the nodal lymphoma had mutations at E1.12. The proportion of hypermutated cases in the group with bcl-6 gene rearrangement was similar to that of the germ-line group (70% v 75%). High frequency of bcl-6 gene hypermutations was found in diffuse large B-cell lymphoma of the stomach and they were independent of rearrangement of the gene as detected by Southern analysis. Unlike gene rearrangement, hypermutations of the bcl-6 gene did not appear to carry any prognostic significance clinically.
对40例香港中国弥漫性大B细胞淋巴瘤患者进行了bcl-6基因高突变的研究。受累的主要部位为淋巴结18例，胃22例。在16/22（73%）原发性胃淋巴瘤和4/18（22%）原发性淋巴结淋巴瘤中可检测到bcl-6基因E1.11节段的高突变（P<0.01）。22例原发性胃淋巴瘤中有3例在E1.12有突变，而淋巴结淋巴瘤均无突变。bcl-6基因重排组的高突变病例比例与种系组相似（70%对75%）。在胃弥漫性大B细胞淋巴瘤中发现bcl-6基因高突变的频率较高，且与Southern分析检测到的基因重排无关。与基因重排不同，bcl-6基因的高突变在临床上似乎没有任何预后意义。
