Adamantane and protoadamantanealkanamines as potential anti-Parkinson agents.
作者信息
Chakrabarti J K, Hotten T M, Sutton S, Tupper D E
出版信息
J Med Chem. 1976 Jul;19(7):967-9. doi: 10.1021/jm00229a022.
PMID:940116
Abstract
The synthesis of 2-halo-1-adamantanemethanamines, 4-protoadamantanemethanamines, and 4-protoadamantaneamines is described. The anti-Parkinson activity of these amines in terms of reversal of reserpine-induced catalepsy in rats has been evaluated and compared with amantadine. 2-Bromo- and 2-chloro-1-adamantanemethanamines are shown to be twice as active as amantadine.
摘要
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