通过构建金刚烷骨架合成1,2-二取代金刚烷衍生物

Synthesis of 1,2-Disubstituted Adamantane Derivatives by Construction of the Adamantane Framework.

作者信息

Todd Matthew, Hrdina Radim

机构信息

Department of Organic Chemistry, Faculty of Science, Charles University, Hlavova 8, 12043 Praha, Czech Republic.

出版信息

Molecules. 2023 Nov 16;28(22):7636. doi: 10.3390/molecules28227636.

DOI:10.3390/molecules28227636

PMID:38005358

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10675813/

Abstract

This review summarizes achievements in the synthesis of 1,2-disubstituted adamantane derivatives by the construction of the tricyclic framework either by total synthesis or by ring expansion/contraction reactions of corresponding adamantane homologues. It is intended to complement reviews focusing on the preparation of 1,2-disubstituted derivatives by C-H functionalization methods.

摘要

本综述总结了通过全合成或相应金刚烷同系物的扩环/缩环反应构建三环骨架来合成1,2-二取代金刚烷衍生物的研究成果。其目的是补充侧重于通过C-H官能化方法制备1,2-二取代衍生物的综述。