Misialek M J, Pechet L
Department of Pathology, University of Massachusetts, Hospital Laboratories and Medical Center, Worcester 01655, USA.
Acta Haematol. 1997;98(4):221-7. doi: 10.1159/000203629.
There exists a great deal of overlap between many myelodysplastic syndromes and myeloproliferative disorders. This is most evident in the spectrum of disorders classified under the term chronic myeloid leukemia. These include chronic granulocytic leukemia, atypical chronic myeloid leukemia and chronic myelomonocytic leukemia. Current classification often does not clearly separate these entities since they share many features, both clinically and hematologically. We report here a case that satisfies criteria for both chronic myelomonocytic leukemia and atypical chronic myeloid leukemia, appearing to fluctuate between the two. This lends further evidence for the heterogeneity of these disorders and the need for better definition. An improved classification scheme would allow for more accurate reporting and research into etiology and treatment. The complex cytogenetic abnormalities of the case are unique and to our knowledge have not been reported previously. Also, this case report underscores the importance of cytochemical stains when such disorders are under consideration.
许多骨髓增生异常综合征和骨髓增殖性疾病之间存在大量重叠。这在归类于慢性髓系白血病这一术语下的疾病谱中最为明显。这些疾病包括慢性粒细胞白血病、非典型慢性髓系白血病和慢性粒单核细胞白血病。目前的分类常常无法清晰地区分这些实体，因为它们在临床和血液学方面都有许多共同特征。我们在此报告一例既符合慢性粒单核细胞白血病又符合非典型慢性髓系白血病标准的病例，该病例似乎在这两种疾病之间波动。这进一步证明了这些疾病的异质性以及更好地进行定义的必要性。改进的分类方案将有助于更准确地报告以及对病因和治疗进行研究。该病例复杂的细胞遗传学异常是独特的，据我们所知此前尚未有过报道。此外，本病例报告强调了在考虑此类疾病时细胞化学染色的重要性。
