Schedin U, Norman M, Gustafsson L E, Jonsson B, Frostell C
Division of Anaesthesia and Intensive Care, Karolinska Institute, Danderyd Hospital, Stockholm, Sweden.
Acta Paediatr. 1997 Nov;86(11):1229-35. doi: 10.1111/j.1651-2227.1997.tb14852.x.
Concentrations of endogenous nitric oxide (NO) were measured in premature (n = 18) and term infants (n = 7). Nasal gas was aspirated continuously and after timed occlusions, 15 s and 60 s, by a fast-response chemiluminescence analyser. The sampling flow rate was 20 ml min-1. Typical NO recordings consisted of plateaux and postocclusive peaks. In term infants peak NO concentrations (60 s occlusion) were 2.71 +/- 0.44 parts per million (ppm) within 10 min after birth, increasing (p < 0.05) to 3.81 +/- 0.25 ppm at 4-7 d postnatally. Peak NO values (15 s occlusion) averaged 1.22 +/- 0.16 ppm in premature infants (postconceptional age 25-37 weeks, body weight 623-2844 g) and the NO concentrations increased significantly with postconceptional age (p < 0.05). Nasal excretion rate, estimated from plateau NO concentrations and sampling flow rate, was 0.10 +/- 0.01 nmol min-1 kg-1 in both groups. We conclude that premature and term newborn infants excrete considerable amounts of NO in the upper airways, with hitherto not fully known functions.
对18名早产儿和7名足月儿的内源性一氧化氮（NO）浓度进行了测量。通过快速响应化学发光分析仪在定时阻塞（15秒和60秒）后连续抽取鼻腔气体。采样流速为20毫升/分钟。典型的NO记录包括平台期和阻塞后峰值。足月儿出生后10分钟内NO峰值浓度（60秒阻塞）为2.71±0.44百万分之一（ppm），出生后4至7天时升高（p<0.05）至3.81±0.25 ppm。早产儿（孕龄25至37周，体重623至2844克）的NO峰值（15秒阻塞）平均为1.22±0.16 ppm，且NO浓度随孕龄显著升高（p<0.05）。根据平台期NO浓度和采样流速估算的鼻腔排泄率，两组均为0.10±0.01纳摩尔/分钟/千克。我们得出结论，早产儿和足月儿在上呼吸道排泄大量NO，其功能迄今尚未完全明确。
