Artlich A, Busch T, Lewandowski K, Schaible T, Falke K J, Gortner L
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Respir Physiol. 1998 Nov;114(2):195-200. doi: 10.1016/s0034-5687(98)00069-3.
Nitric oxide (NO) is detectable in the exhaled gas of adults during spontaneous respiration and, according to current knowledge, mainly originates from the paranasal sinuses. We studied total NO excretion rates by chemiluminescence in preterm infants whose paranasal sinuses are known to be only partially pneumatized. NO excretion was 7.15 +/- 1.13 nl/min (mean +/- SD, range 6.33-9.36 nl/min) measured from spontaneously exhaled nasal gas (n = 6) and 0.3 +/- 0.05 nl/min (range 0.26-0.36 nl/min) measured from the lower airways in intubated individuals (n = 3). These values are considerably lower than those reported for older children and adults. Body weight-related amounts of NO excretion, however, seem comparable between infants and adults.
在自然呼吸过程中，一氧化氮（NO）可在成人呼出气体中检测到，根据目前的认知，其主要来源于鼻窦。我们通过化学发光法研究了早产儿的总NO排泄率，已知早产儿的鼻窦仅部分气化。从自发呼出的鼻腔气体中测得的NO排泄率为7.15±1.13 nl/分钟（平均值±标准差，范围6.33 - 9.36 nl/分钟）（n = 6），在插管个体的下呼吸道中测得的为0.3±0.05 nl/分钟（范围0.26 - 0.36 nl/分钟）（n = 3）。这些值远低于年长儿童和成人的报道值。然而，与体重相关的NO排泄量在婴儿和成人之间似乎具有可比性。
