Seahorn T L, Beadle R E, McGorum B C, Marley C L
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
Am J Vet Res. 1997 Dec;58(12):1408-11.
To determine whether horses with summer pasture-associated obstructive pulmonary disease (SPAOPD) have increased concentrations of antigen-specific IgG and IgE in tracheal lavage fluid, compared with values in clinically normal horses.
8 horses (6 females, 2 geldings; 6 Quarter Horses, 2 Appaloosas), 14 to 23 years old and with previous diagnosis of SPAOPD, served as the principal group; 8 horses (2 females, 6 geldings; 1 Quarter Horse, 7 Thoroughbreds), 6 to 9 years old, with no evidence of respiratory tract disease, served as the control group.
Data were collected twice during a 1-year period: when all SPAOPD-affected horses were manifesting clinical signs of disease (July), and when all SPAOPD-affected horses appeared clinically normal (February). On each occasion, clinical evaluations were performed and blood and tracheal lavage fluid samples were collected. Transtracheal lavage supernatant was evaluated for mold antigen-specific IgG and IgE concentrations.
Median IgE relative antibody unit (RAU) values were significantly higher in control, compared with principal, horses. The SPAOPD-affected horses had increased concentrations of specific IgG for only 1 antigen, during winter sample collection.
Antigen-specific IgG and IgE RAU values were not increased in SPAOPD-affected horses when these horses were manifesting clinical signs of disease.
确定与临床正常马匹相比，患有夏季牧场相关阻塞性肺病（SPAOPD）的马匹气管灌洗液中抗原特异性IgG和IgE的浓度是否升高。
8匹马（6匹母马，2匹阉马；6匹夸特马，2匹阿帕卢萨马），年龄在14至23岁之间，先前诊断为SPAOPD，作为主要组；8匹马（2匹母马，6匹阉马；1匹夸特马，7匹纯种马），年龄在6至9岁之间，无呼吸道疾病迹象，作为对照组。
在1年期间收集两次数据：当所有受SPAOPD影响的马匹出现疾病临床症状时（7月），以及当所有受SPAOPD影响的马匹临床症状正常时（2月）。每次都进行临床评估，并采集血液和气管灌洗液样本。评估经气管灌洗上清液中霉菌抗原特异性IgG和IgE的浓度。
与主要组马匹相比，对照组马匹的IgE相对抗体单位（RAU）中位数显著更高。在冬季样本采集期间，受SPAOPD影响的马匹仅对1种抗原的特异性IgG浓度有所升高。
当受SPAOPD影响的马匹出现疾病临床症状时，其抗原特异性IgG和IgE的RAU值并未升高。
