Burton S A, Lemke K A, Ihle S L, Mackenzie A L
Department of Pathology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada.
Am J Vet Res. 1997 Dec;58(12):1440-2.
To determine the effects of medetomidine, administered i.v., on serum insulin and plasma glucose concentrations in clinically normal dogs.
6 healthy adult Beagles.
Dogs were randomly assigned to each of 3 treatments in a prospective cross-over study design. Serum insulin and plasma glucose concentrations were determined before and 20, 40, 60, 120, 180, 240, 300, 360, 420, and 480 minutes after i.v. administration of 0.9% NaCl solution (control) or medetomidine (10 or 20 micrograms/kg of body weight).
Mean serum insulin concentration decreased after medetomidine administration and was significantly (P < or = 0.05) lower than control values 20, 40, 60, and 120 minutes after drug administration. Mean plasma glucose concentration tended to increase after medetomidine administration, but did not differ significantly from control values.
In dogs, i.v. administration of medetomidine at dosages of 10 and 20 micrograms/kg transiently decreases serum insulin concentration, but plasma glucose concentration remains within the normal physiologic range.
Medetomidine can be given at low, preanesthetic dosages without significantly altering plasma glucose concentration in clinically normal dogs.
确定静脉注射美托咪定对临床正常犬血清胰岛素和血浆葡萄糖浓度的影响。
6只健康成年比格犬。
在一项前瞻性交叉研究设计中，将犬随机分为3组进行每种治疗。在静脉注射0.9%氯化钠溶液（对照组）或美托咪定（10或20微克/千克体重）之前以及给药后20、40、60、120、180、240、300、360、420和480分钟时测定血清胰岛素和血浆葡萄糖浓度。
注射美托咪定后平均血清胰岛素浓度降低，且在给药后20、40、60和120分钟时显著低于对照组值（P≤0.05）。注射美托咪定后平均血浆葡萄糖浓度有升高趋势，但与对照组值无显著差异。
在犬中，静脉注射剂量为10和20微克/千克的美托咪定可使血清胰岛素浓度短暂降低，但血浆葡萄糖浓度保持在正常生理范围内。
在临床正常犬中，可在麻醉前给予低剂量美托咪定，而不会显著改变血浆葡萄糖浓度。
