• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Distribution of D-amino acid oxidase (DAO) activity in the medulla and thoracic spinal cord of the rat: implications for a role for D-serine in autonomic function.

作者信息

Kappor R, Kapoor V

机构信息

School of Physiology and Pharmacology, University of New South Wales, Sydney, Australia.

出版信息

Brain Res. 1997 Oct 17;771(2):351-5. doi: 10.1016/s0006-8993(97)00886-x.

DOI:10.1016/s0006-8993(97)00886-x
PMID:9401756
Abstract

The activity and regional distribution of D-amino acid oxidase (DAO), an enzyme that inactivates D-serine, were examined in the medulla and spinal cord of the rat by biochemical and histochemical procedures. DAO activity was noticeably low or absent in the nucleus of the solitary tract, ventrolateral medulla and intramediolateral cell column of the spinal cord. This may be indicative of a neuromodulatory role for endogenous D-serine (at the NMDA-glycine site) in in the central control of blood pressure.

摘要

相似文献

1
Distribution of D-amino acid oxidase (DAO) activity in the medulla and thoracic spinal cord of the rat: implications for a role for D-serine in autonomic function.
Brain Res. 1997 Oct 17;771(2):351-5. doi: 10.1016/s0006-8993(97)00886-x.
2
Immuno-localization of kynurenine aminotransferase (KAT) in the rat medulla and spinal cord.
Neuroreport. 1997 Nov 10;8(16):3619-23. doi: 10.1097/00001756-199711100-00039.
3
Altered responsiveness of medullary depressor neurones to L-glutamate and D-serine in SHR rats.自发性高血压大鼠延髓降压神经元对L-谷氨酸和D-丝氨酸的反应性改变
Neuroreport. 1996 May 31;7(8):1409-12. doi: 10.1097/00001756-199605310-00017.
4
Spinal NMDA receptors mediate pressor responses evoked from the rostral ventrolateral medulla.
Am J Physiol. 1991 Jan;260(1 Pt 2):H267-75. doi: 10.1152/ajpheart.1991.260.1.H267.
5
Distribution of glutamate- and GABA-immunoreactive neurons projecting to the cardioacceleratory center of the intermediolateral nucleus of the thoracic cord of SHR and WKY rats: a double-labeling study.
Brain Res. 1994 Feb 28;638(1-2):139-50. doi: 10.1016/0006-8993(94)90643-2.
6
NMDA receptors in the intermediolateral column of the spinal cord mediate sympathoexcitatory cardiac responses elicited from the ventrolateral medullary pressor area.
Brain Res. 1991 Mar 22;544(1):33-41. doi: 10.1016/0006-8993(91)90882-v.
7
Distribution of serine hydroxymethyltransferase and glycine transaminase in several areas of the central nervous system of the rat.丝氨酸羟甲基转移酶和甘氨酸转氨酶在大鼠中枢神经系统几个区域的分布
J Neurochem. 1974 Jun;22(6):877-85. doi: 10.1111/j.1471-4159.1974.tb04312.x.
8
The effect of central amino acid neurotransmitters on the antihypertensive response to angiotensin blockade in spontaneous hypertension.中枢氨基酸神经递质对自发性高血压大鼠血管紧张素阻断降压反应的影响
J Hypertens. 1995 Dec;13(12 Pt 2):1624-30.
9
Age- and gender-dependent D-amino acid oxidase activity in mouse brain and peripheral tissues: implication for aging and neurodegeneration.年龄和性别依赖性 D-氨基酸氧化酶活性在小鼠脑和外周组织中的作用：对衰老和神经退行性变的影响。
J Biochem. 2019 Aug 1;166(2):187-196. doi: 10.1093/jb/mvz025.
10
Attenuation of angiotensin type 2 receptor function in the rostral ventrolateral medullary pressor area of the spontaneously hypertensive rat.自发性高血压大鼠延髓头端腹外侧加压区血管紧张素2型受体功能的减弱
Clin Exp Hypertens. 2016;38(2):209-17. doi: 10.3109/10641963.2015.1081229. Epub 2016 Jan 28.

引用本文的文献

1
Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism.人类D-天冬氨酸氧化酶：D-天冬氨酸代谢中的关键参与者。
Front Mol Biosci. 2021 Jun 23;8:689719. doi: 10.3389/fmolb.2021.689719. eCollection 2021.
2
Biochemical Properties of Human D-amino Acid Oxidase Variants and Their Potential Significance in Pathologies.人D-氨基酸氧化酶变体的生化特性及其在病理学中的潜在意义
Front Mol Biosci. 2018 Jun 12;5:55. doi: 10.3389/fmolb.2018.00055. eCollection 2018.
3
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
D-氨基酸氧化酶介导的脊髓过氧化氢增加主要负责福尔马林诱导的强直痛。
Br J Pharmacol. 2012 Mar;165(6):1941-1955. doi: 10.1111/j.1476-5381.2011.01680.x.
4
Metabolism of the neuromodulator D-serine.神经调质 D-丝氨酸的代谢。
Cell Mol Life Sci. 2010 Jul;67(14):2387-404. doi: 10.1007/s00018-010-0307-9. Epub 2010 Mar 2.
5
Inhibition of D-amino-Acid oxidase activity induces pain relief in mice.抑制D-氨基酸氧化酶活性可减轻小鼠疼痛。
Cell Mol Neurobiol. 2008 Jun;28(4):581-91. doi: 10.1007/s10571-007-9200-y. Epub 2007 Sep 15.