Austin L, Bower J J, Kurek J B, Muldoon C M
Melbourne Neuromuscular Research Centre, St Vincent's Hospital, Australia.
Growth Factors. 1997;15(1):61-8. doi: 10.3109/08977199709002112.
Leukaemia inhibitory factor (LIF) has been shown to effectively enhance skeletal muscle regeneration after mechanical injury and it may have potential therapeutic use in the muscular dystrophies as well as peripheral nerve repair after injury. When LIF is applied systemically to an animal, it is rapidly removed with a biological half life of only a few minutes, and at high doses it exhibits toxic effects. Calcium alginate rods have been developed for the purpose of insertion adjacent to skeletal muscles. These rods, when charged with LIF will release the growth factor to the muscle at a rate of less than 1% per day and for a period extending to several months. In addition, tubes of alginate are described which will be suitable for the continuous supply of LIF to repaired peripheral nerve.
白血病抑制因子（LIF）已被证明能有效促进机械损伤后骨骼肌的再生，并且它在肌肉营养不良以及损伤后周围神经修复方面可能具有潜在的治疗用途。当将LIF全身应用于动物时，它会迅速被清除，生物半衰期仅为几分钟，而且高剂量时会表现出毒性作用。已开发出用于插入骨骼肌附近的海藻酸钙棒。这些棒在装载LIF后，将以每天低于1%的速率向肌肉释放生长因子，释放期可长达数月。此外，还描述了适合向修复后的周围神经持续供应LIF的海藻酸盐管。
