Kullendorff C M, Wiebe T
Department of Paediatric Surgery, University Hospital, Lund, Sweden.
Eur J Pediatr Surg. 1997 Oct;7(5):286-7. doi: 10.1055/s-2008-1071173.
In 26 consecutive patients operated for Wilms' tumour samples from the tumour were genetically analyzed. Clonal acquired chromosome aberrations were found in 13 patients and a constitutional trisomy 18 as the sole change in 1. The chromosome number was altered in 13 patients. Numerical changes occurred in 16 patients and breakpoint of chromosome 1 in 6 patients. There was no structural alteration of chromosome 11. The observed cytogenetic heterogeneity illustrates the complexity of genetic changes involved in the genesis and progression of Wilms' tumour. To further elucidate the phenotypic impact of chromosomal aberrations the correlation to histology and the clinical course will be important.
对26例接受威尔姆斯瘤手术的连续患者的肿瘤样本进行了基因分析。在13例患者中发现了克隆性获得性染色体畸变，1例患者存在作为唯一变化的体质性18三体。13例患者的染色体数目发生改变。16例患者出现数目变化，6例患者出现1号染色体断点。11号染色体无结构改变。观察到的细胞遗传学异质性说明了威尔姆斯瘤发生和进展中涉及的基因变化的复杂性。为了进一步阐明染色体畸变的表型影响，与组织学和临床病程的相关性将很重要。
