Crocker A D
Department of Clinical Pharmacology, Flinders University of South Australia, Australia.
Rev Neurosci. 1997 Jan-Mar;8(1):55-76. doi: 10.1515/revneuro.1997.8.1.55.
The importance of the nigrostriatal dopaminergic pathway in motor control is widely accepted and it is generally believed that the motor symptoms of Parkinson's disease result solely from reduced release of dopamine from terminals in the striatum. Over recent years there has been a growing body of evidence which suggests that dendritic dopamine release in the substantia nigra is of importance in the regulation of neuronal activity and behaviour. This evidence is reviewed together with a description of our recent findings that show nigral dopamine receptors are essential for the maintenance of normal muscle tone. It is concluded that current views of the basal ganglia circuitry involved in motor control need to be re-evaluated to take into account these recent reports. A scheme is suggested to explain how dopamine mechanisms in the substantia nigra regulate motor activity.
黑质纹状体多巴胺能通路在运动控制中的重要性已被广泛接受，人们普遍认为帕金森病的运动症状完全是由于纹状体中多巴胺能终末释放减少所致。近年来，越来越多的证据表明，黑质中的树突状多巴胺释放对于神经元活动和行为的调节具有重要意义。本文将对这些证据进行综述，并描述我们最近的研究结果，这些结果表明黑质多巴胺受体对于维持正常肌张力至关重要。本文得出结论，需要重新评估目前关于参与运动控制的基底神经节回路的观点，以考虑到这些最新报告。本文提出了一个方案来解释黑质中的多巴胺机制是如何调节运动活动的。
