Hemsley K M, Crocker A D
Department of Clinical Pharmacology, Flinders University of South Australia, Adelaide, Australia.
Neurosci Lett. 1998 Jul 24;251(2):77-80. doi: 10.1016/s0304-3940(98)00463-7.
Recent evidence has questioned the view that the increased muscle tone of Parkinson's disease results solely from reduced release of dopamine in the striatum, by emphasising the important role of the substantia nigra. The aim of the current study was to compare the effects on muscle tone of inactivating D1 and D2 dopamine receptors throughout the brain with those seen following their inactivation only in the substantia nigra. Inactivation of dopamine receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline injected either intraperitoneally, or bilaterally into the substantia nigra, resulted in similar increases in muscle tone, measured as changes in tonic electromyographic (EMG) activity. The magnitude and onset of EMG increases was related to the level of dopamine receptor inactivation. The results are consistent with the hypothesis that nigral dopamine mechanisms play a key role in the maintenance of muscle tone.
最近有证据对帕金森病肌肉张力增加仅源于纹状体中多巴胺释放减少这一观点提出了质疑，该证据强调了黑质的重要作用。本研究的目的是比较在全脑灭活D1和D2多巴胺受体与仅在黑质灭活这些受体后对肌肉张力的影响。通过腹腔注射或双侧注射到黑质中的N - 乙氧羰基 - 2 - 乙氧基 - 1,2 - 二氢喹啉来灭活多巴胺受体，导致肌肉张力出现类似的增加，这是以强直肌电图（EMG）活动的变化来衡量的。EMG增加的幅度和起始与多巴胺受体灭活的程度有关。这些结果与黑质多巴胺机制在维持肌肉张力中起关键作用的假设是一致的。
