Niedner R
Department of Dermatology, Potsdam, Germany.
Dermatology. 1997;195 Suppl 2:89-92. doi: 10.1159/000246038.
Povidone-iodine is an antiseptic widely used in dermatology. In vitro experiments showed a certain cytotoxicity, yet it is not easy to transfer these toxicological data to in vivo circumstances. In vivo investigations in animals and in humans could exclude cytotoxic effects of povidone-iodine, measured by the wound healing process. Only when administered in combination with detergents was an obvious cytotoxicity seen in wounds but not on the intact skin. In comparison to the frequently used antibiotic neomycin, the sensitization rate of povidone-iodine is very low.
聚维酮碘是一种在皮肤科广泛使用的防腐剂。体外实验显示出一定的细胞毒性，但将这些毒理学数据转化到体内环境并不容易。在动物和人体进行的体内研究表明，通过伤口愈合过程测量，聚维酮碘没有细胞毒性作用。只有当与洗涤剂联合使用时，才会在伤口处观察到明显的细胞毒性，但在完整皮肤上则不会出现。与常用抗生素新霉素相比，聚维酮碘的致敏率非常低。
