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人巨细胞病毒感染后单核细胞产生超氧化物。

Superoxide generation by monocytes following infection with human cytomegalovirus.

作者信息

Suzuki S, Kameoka M, Nakaya T, Kimura T, Nishi N, Hirai K, Ikuta K

机构信息

Section of Serology, Institute of Immunological Science, Hokkaido University, Sapporo, Japan.

出版信息

Immunopharmacology. 1997 Oct;37(2-3):185-90. doi: 10.1016/s0162-3109(97)00047-7.

Abstract

A significant level of superoxide (O2-) generation was observed in a U937-derived subclone following infection with human cytomegalovirus (HCMV). Although there were no detectable levels of viral mRNA and/or protein expression, HCMV DNA content transiently increased immediately before O2- generation. Similarly, O2- generation was also observed in peripheral blood monocytes derived from healthy donors.

摘要

在人巨细胞病毒(HCMV)感染后的U937衍生亚克隆中观察到显著水平的超氧化物(O2-)生成。尽管未检测到病毒mRNA和/或蛋白表达水平,但在O2-生成之前,HCMV DNA含量短暂增加。同样,在来自健康供体的外周血单核细胞中也观察到了O2-生成。

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