Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1400 Holcombe Blvd., Unit 442, Houston, TX 77030, USA.
Neuro Oncol. 2012 Mar;14(3):246-55. doi: 10.1093/neuonc/nor227. Epub 2012 Feb 8.
The human cytomegalovirus (HCMV) and glioma symposium was convened on April 17, 2011 in Washington, DC, and was attended by oncologists and virologists involved in studying the relationship between HCMV and gliomas. The purpose of the meeting was to reach a consensus on the role of HCMV in the pathology of gliomas and to clarify directions for future research. First, the group summarized data that describe how HCMV biology overlaps with the key pathways of cancer. Then, on the basis of published data and ongoing research, a consensus was reached that there is sufficient evidence to conclude that HCMV sequences and viral gene expression exist in most, if not all, malignant gliomas, that HCMV could modulate the malignant phenotype in glioblastomas by interacting with key signaling pathways; and that HCMV could serve as a novel target for a variety of therapeutic strategies. In summary, existing evidence supports an oncomodulatory role for HCMV in malignant gliomas, but future studies need to focus on determining the role of HCMV as a glioma-initiating event.
人巨细胞病毒 (HCMV) 和神经胶质瘤研讨会于 2011 年 4 月 17 日在华盛顿特区召开，参会者包括从事 HCMV 与神经胶质瘤关系研究的肿瘤学家和病毒学家。会议的目的是就 HCMV 在神经胶质瘤病理学中的作用达成共识，并明确未来研究的方向。首先，该小组总结了描述 HCMV 生物学与癌症关键途径重叠的数据。然后，根据已发表的数据和正在进行的研究，达成了一项共识，即有充分的证据表明，HCMV 序列和病毒基因表达存在于大多数（如果不是全部）恶性神经胶质瘤中，HCMV 可以通过与关键信号通路相互作用来调节神经母细胞瘤的恶性表型；HCMV 可以作为各种治疗策略的新靶点。总之，现有证据支持 HCMV 在恶性神经胶质瘤中具有致癌调节作用，但未来的研究需要集中于确定 HCMV 作为神经胶质瘤起始事件的作用。
