Chigusa S, Kaetsu H, Ikegaki J, Kimura Y, Obara H
Department of Anesthesia, Hyogo Medical Center for Adults, Akashi.
Masui. 1997 Nov;46(11):1465-9.
Propofol has been reported to reduce emesis. This study was performed to evaluate the incidence of postoperative nausea and vomiting (PONV) in gynecologic abdominal surgery patients after propofol anesthesia and inhalational anesthesia. Sixty patients were evaluated for the incidence of PONV. Thirty patients received oxygen-propofol-epidural anesthesia (propofol group) and the others were maintained with nitrous oxide-oxygen-isoflurane/sevoflurane--epidural anesthesia (inhalational group). The incidence of PONV was 33.3% in propofol group and 60% in inhalational group (P < 0.05). The means of frequency of postoperative nausea were 0.63 and 1.97 in propofol-group and inhalational group, respectively (P < 0.05). Those of postoperative vomiting were 0.17 after propofol and 1.00 following inhalational anesthesia (P < 0.01). For the gynecologic abdominal surgery patients, PONV was significantly less following intravenous anesthesia with propofol than after isoflurane or sevoflurane inhalational anesthesia. This study indicated that propofol anesthesia was useful in reducing PONV after gynecologic abdominal surgery.
据报道,丙泊酚可减少呕吐。本研究旨在评估丙泊酚麻醉和吸入麻醉后妇科腹部手术患者术后恶心呕吐(PONV)的发生率。对60例患者的PONV发生率进行了评估。30例患者接受氧气 - 丙泊酚 - 硬膜外麻醉(丙泊酚组),其余患者采用氧化亚氮 - 氧气 - 异氟烷/七氟烷 - 硬膜外麻醉(吸入组)。丙泊酚组PONV发生率为33.3%,吸入组为60%(P < 0.05)。丙泊酚组和吸入组术后恶心频率平均值分别为0.63和1.97(P < 0.05)。丙泊酚麻醉后术后呕吐频率为0.17,吸入麻醉后为1.00(P < 0.01)。对于妇科腹部手术患者,丙泊酚静脉麻醉后PONV明显少于异氟烷或七氟烷吸入麻醉后。本研究表明,丙泊酚麻醉有助于减少妇科腹部手术后的PONV。