Khan F A, Zaidi A, Kamal R S
Department of Anaesthesia, Aga Khan University Hospital, Karachi, Pakistan.
Anaesthesia. 1997 Nov;52(11):1095-101. doi: 10.1111/j.1365-2044.1997.211-az0347.x.
Nalbuphine (0.3 mg.kg-1) and buprenorphine (2.5 micrograms.kg-1) were compared as part of a total intravenous anaesthesia regimen using a propofol infusion in 60 patients undergoing laparoscopic cholecystectomy in a randomised double-blind study. Changes in haemodynamic variables greater than 20% from the baseline were noted. No difference was observed in blood pressure but the heart rate was significantly lower in the buprenorphine group. Intra-operative bradycardia (heart rate < 60 beat.min-1) occurred more often in the buprenorphine group. Recovery was fast and comparable with both drugs and no patient reported awareness. Quality of analgesia was similar in both groups. Both drugs provide suitable analgesic supplementation to total intravenous anaesthesia.
在一项随机双盲研究中，对60例接受腹腔镜胆囊切除术的患者，将纳布啡（0.3毫克·千克⁻¹）和丁丙诺啡（2.5微克·千克⁻¹）作为使用丙泊酚输注的全静脉麻醉方案的一部分进行比较。记录了血流动力学变量相对于基线变化大于20%的情况。未观察到血压有差异，但丁丙诺啡组的心率显著较低。丁丙诺啡组术中心动过缓（心率<60次·分钟⁻¹）发生得更频繁。恢复迅速，两种药物的情况相当，且无患者报告有术中知晓。两组的镇痛质量相似。两种药物都为全静脉麻醉提供了合适的镇痛补充。
