Fieni F, Dumon C, Tainturier D, Bruyas J F
Department of Clinical Sciences, National Veterinary School, Nantes, France.
J Reprod Fertil Suppl. 1997;51:245-50.
Sixty-seven pregnant bitches were given atropine sulphate (0.025 mg kg-1), prifinium bromide (0.1 ml kg-1) and metopimazine (0.5 mg kg-1) and 15 min later 2.5 micrograms cloprostenol kg-1 s.c., three times at 48 h intervals (day 1, day 3, day 5). After one treatment, 53 of the 67 bitches had aborted, and after a second treatment, 62 of the 67 bitches had aborted. In 18 bitches, progesteronemia kinetics were followed-up: the first injection of cloprostenol resulted in a significant (P < 0.01) fall in progesteronemia. In 12 of the 18 bitches that had aborted following the first protocol, this rapid fall in progesterone was noteworthy as it decreased progesterone concentration on average from 17.07 +/- 8.20 ng ml-1 on day 1 to 1.31 +/- 0.34 ng ml-1 on day 3. The premedication administered 15 min before the injection of prostaglandins, prevented the appearance of side effects in 39 of the 67 bitches (58.2%).
67只怀孕母犬被给予硫酸阿托品（0.025毫克/千克）、溴化普里芬铵（0.1毫升/千克）和甲哌氯丙嗪（0.5毫克/千克），15分钟后皮下注射2.5微克氯前列醇/千克，每隔48小时注射一次（第1天、第3天、第5天），共注射三次。一次治疗后，67只母犬中有53只流产；二次治疗后，67只母犬中有62只流产。对18只母犬的孕酮血症动力学进行了跟踪：首次注射氯前列醇导致孕酮血症显著（P<0.01）下降。在首次治疗方案后流产的18只母犬中，有12只母犬孕酮的这种快速下降值得注意，因为孕酮浓度平均从第1天的17.07±8.20纳克/毫升降至第3天的1.31±0.34纳克/毫升。在注射前列腺素前15分钟给予的术前用药，使67只母犬中的39只（58.2%）未出现副作用。
