Lange K, Günzel-Apel A R, Hoppen H O, Mischke R, Nolte I
Department of Reproductive Medicine, School of Veterinary Medicine, Hannover, Germany.
J Reprod Fertil Suppl. 1997;51:251-7.
Three groups of five beagle bitches were treated three times a day with natural prostaglandin F2 alpha (PGF2 alpha) at a dosage of either 20 micrograms kg-1 bodyweight (days 5-8 of metoestrus), 50 micrograms kg-1 bodyweight (days 5-11 of metoestrus) or 20 micrograms kg-1 bodyweight after detection of pregnancy (days 20-21 after ovulation) for 7 days. A dose of 20 micrograms PGF2 alpha kg-1 bodyweight administered during the early luteal stage could not induce a reliable decrease of progesterone concentrations, while injections of 50 micrograms PGF2 alpha kg-1 bodyweight beginning before implantation resulted in arrest of luteal progesterone production and prevention of nidation in all five bitches. The application of 20 micrograms PGF2 alpha kg-1 bodyweight shortly after implantation induced functional arrest of corpora lutea and led to embryonic or fetal resorption in all cases. In general, the luteolytic effect of low PGF2 alpha doses was insufficient because of the recovery of the corpora lutea seen in nearly all bitches and the prolonged process of embryonic or fetal resorption that increase the risk of uterine disease.
将三组各五只比格犬母犬，每天用天然前列腺素F2α（PGF2α）治疗三次，剂量分别为20微克/千克体重（发情后期第5 - 8天）、50微克/千克体重（发情后期第5 - 11天）或在检测到怀孕后（排卵后第20 - 21天）20微克/千克体重，持续7天。在黄体早期给予20微克PGF2α/千克体重的剂量不能可靠地降低孕酮浓度，而在着床前开始注射50微克PGF2α/千克体重导致所有五只母犬黄体孕酮生成停止并防止着床。着床后不久应用20微克PGF2α/千克体重导致黄体功能停止，并在所有情况下导致胚胎或胎儿吸收。一般来说，低剂量PGF2α的溶黄体作用不足，因为几乎所有母犬的黄体都恢复了，并且胚胎或胎儿吸收过程延长，增加了子宫疾病的风险。
