接触狄氏剂和艾氏剂的工人死亡率：一项回顾性队列研究。
Mortality of workers exposed to dieldrin and aldrin: a retrospective cohort study.
作者信息
de Jong G, Swaen G M, Slangen J J
机构信息
Shell International BV, Den Haag, The Netherlands.
出版信息
Occup Environ Med. 1997 Oct;54(10):702-7. doi: 10.1136/oem.54.10.702.
OBJECTIVE
To investigate the occurrence of long term health effects in humans exposed to aldrin and dieldrin, with an update of an earlier retrospective cohort mortality study.
METHODS
A group of 570 workers employed between 1 January 1954 and 1 January 1970 either in a production or formulation plant were followed up for mortality until 1 January 1993. There were extensive industrial hygiene data available and biological monitoring data of aldrin and dieldrin for most of the workers. From these data individual estimates were made of the total intake of dieldrin. A total number of 2539.37 person-years at risk was added to the original study.
RESULTS
118 deaths were observed compared with 156 expected. No increase in mortality from liver cancer was found. However, there was an excess in mortality from rectal cancer. This excess was inversely related to the dose gradient. An analysis by job title did not show any excess cancer in any particular job.
CONCLUSION
The study does not support a carcinogenic effect of dieldrin and aldrin in humans.
目的
通过更新一项早期的回顾性队列死亡率研究，调查接触艾氏剂和狄氏剂的人群中长期健康影响的发生情况。
方法
对1954年1月1日至1970年1月1日期间在生产厂或配方厂工作的570名工人进行随访，直至1993年1月1日，记录其死亡率。有大量的工业卫生数据可用，并且大多数工人都有艾氏剂和狄氏剂的生物监测数据。根据这些数据，对狄氏剂的总摄入量进行了个体估计。在原研究基础上增加了总计2539.37人年的风险。
结果
观察到118例死亡，预期死亡数为156例。未发现肝癌死亡率增加。然而，直肠癌死亡率过高。这种过高与剂量梯度呈负相关。按职称进行的分析未显示任何特定工作中有癌症过高的情况。
结论
该研究不支持狄氏剂和艾氏剂对人类具有致癌作用。
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