Decréau R, Viola A, Hadjur C, Richard M J, Jeunet A, Favier A, Julliard M
Laboratoire AM3-ESA CNRS 6009, Faculté des Sciences Saint-Jérôme, Marseille, France.
C R Seances Soc Biol Fil. 1997;191(4):639-57.
Photodynamic therapy of cancerous cells is a technique relying upon the irradiation of tumorous cells after selective incorporation of a photosensitizer. The bis (tri n-hexylsiloxy) silicon phthalocyanine is a second generation photosensitizer. Anti-cancerous potentialities of this molecule have been evaluated against the melanotic M6 cell line. Results have evidenced a high phototoxicity at low concentration and no dark toxicity under the same conditions. EPR studies on the photochemical pathways involved in phototoxicity processes have been realised in solvent and model membranes (liposomes). Results provide evidences for the production of singlet oxygen (1O2) as well as superoxide (02(o)-) and hydroxyl radicals (0OH).
癌细胞的光动力疗法是一种在选择性掺入光敏剂后对肿瘤细胞进行照射的技术。双（三正己基硅氧基）硅酞菁是第二代光敏剂。已针对黑色素瘤M6细胞系评估了该分子的抗癌潜力。结果表明，在低浓度下具有高光毒性，在相同条件下无暗毒性。已在溶剂和模型膜（脂质体）中对光毒性过程中涉及的光化学途径进行了电子顺磁共振研究。结果为单线态氧（1O2）以及超氧阴离子（02（o）-）和羟基自由基（0OH）的产生提供了证据。
