Miélot F, Bader-Meunier B, Tchernia G, Dommergues J P
Laboratoire d'Hématologie, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Pathol Biol (Paris). 1997 Sep;45(7):594-9.
Sideroblastic anemia associated with vacuolization of haemopoietic precursors can be observed in some constitutional diseases associated with mitochondrial DNA deletion. In this condition, it is the haematological expression of a multi-tissue disorder. Haemopoiesis is polyclonal, without abnormality of nuclear DNA differing from the acquired idiopathic sideroblastic anemias which arise from a clonal transformed stem cell. This model of childhood polyclonal myelodysplasia can be observed in others myelodysplasias associated with constitutional polymalformative syndromes.
