Copray J C, Brouwer N
Department of Medical Physiology, University of Groningen, Netherlands.
Neurosci Lett. 1997 Oct 24;236(1):41-4. doi: 10.1016/s0304-3940(97)00747-7.
We have studied the regulation of the expression of neurotrophin-3 (NT-3) mRNA in neonatal and adult rat muscle spindles after denervation and after denervation followed by reinnervation. Denervation of the intrafusal fibres did not result in an upregulation of the NT-3 mRNA expression but decreased this expression below the detection limit of the in situ hybridization method. Reinnervation of intrafusal fibres restored the NT-3 mRNA expression. The results suggest that the expression of NT-3 mRNA in postnatal muscle spindles is controlled by neuronal factors. The intrafusal fibre derived NT-3 may act as an instructive, feedback messenger for innervating neurons and may play a role in stabilizing and maintaining functional neuromuscular connections.
我们研究了去神经支配以及去神经支配后再支配的新生和成年大鼠肌梭中神经营养因子-3（NT-3）mRNA表达的调节。梭内肌纤维去神经支配并未导致NT-3 mRNA表达上调，反而使其表达降低至原位杂交方法的检测限以下。梭内肌纤维再支配恢复了NT-3 mRNA表达。结果表明，出生后肌梭中NT-3 mRNA的表达受神经元因子控制。梭内肌纤维衍生的NT-3可能作为一种指导性的反馈信使作用于支配神经元，并可能在稳定和维持功能性神经肌肉连接中发挥作用。
