Tanchot C, Rosado M M, Agenes F, Freitas A A, Rocha B
INSERM U345, Institut Necker, 156 Rue Vaugirard, Paris, 75015, France.
Semin Immunol. 1997 Dec;9(6):331-7. doi: 10.1006/smim.1997.0090.
B- and T-lymphocyte populations have an independent homeostatic regulation of resting (B and T) and activated (B) or memory (T) cell compartments. This organization may provide an efficient mechanism to ensure simultaneously a first natural barrier of protection against common pathogens, the maintenance of immunological T-cell memory and a reservoir of repertoire diversity capable of dealing with new antigenic challenges.
B淋巴细胞和T淋巴细胞群体对静止(B细胞和T细胞)以及活化(B细胞)或记忆(T细胞)细胞区室具有独立的稳态调节。这种组织方式可能提供一种有效的机制,以同时确保针对常见病原体的第一道天然保护屏障、免疫T细胞记忆的维持以及能够应对新抗原挑战的库多样性储备。