Cahill R N, Kimpton W G, Cunningham C P, Washington E A
Laboratory for Fetal and Neonatal Immunology, The University of Melbourne, Cnr Flemington Road and Park Drive, Parkville, Victoria, 3052, Australia.
Semin Immunol. 1997 Dec;9(6):355-63. doi: 10.1006/smim.1997.0093.
Lymphocyte recirculation is an essential element in the integration of immune responses and is an absolute requirement for the development of systemic memory in postnatal animals. During foetal life a large pool of recirculating T cells develops and migration pathways of naive T cells to skin and peripheral tissues as well as LN are established. At birth a process is triggered whereby naive fetal T cells are rapidly lost from the circulating pool and are replaced by newly arriving T cells which have been formed since birth. At present our data suggest that the thymic export in the fetus creates a pool of long-lived naive T cells of wide diversity. The situation in neonatal lambs is more complex since the thymus is exporting large numbers of short-lived thymic emigrants which enter a peripheral T-cell population where many T cells are dividing.
淋巴细胞再循环是免疫反应整合的一个基本要素，也是出生后动物全身记忆形成的绝对必要条件。在胎儿期，大量循环T细胞池形成，幼稚T细胞向皮肤、外周组织以及淋巴结的迁移途径得以建立。出生时，一个过程被触发，幼稚胎儿T细胞迅速从循环池中消失，并被出生后新形成的T细胞所取代。目前我们的数据表明，胎儿期胸腺输出产生了一个高度多样化的长寿幼稚T细胞池。新生羔羊的情况更为复杂，因为胸腺正在输出大量短命的胸腺迁出细胞，这些细胞进入外周T细胞群体，其中许多T细胞正在分裂。
