Tough D F, Sprent J
Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA.
Stem Cells. 1995 May;13(3):242-9. doi: 10.1002/stem.5530130305.
The life span of mature T cells is reviewed. Peripheral T lymphocytes are a heterogeneous population and comprise a mixture of naive, effector and memory cells. The recirculating pool of mature T cells is formed during young life through gradual release of naive T cells from the thymus. In adults, the pool of mature T cells is relatively self-sufficient, and input of new T cells from the thymus declines to low levels. Studies on T cell turnover indicate that most peripheral T cells can remain in a resting state for long periods (months in rodents and years in humans). Examination of the phenotype of dividing versus nondividing cells suggests that typical naive T cells are long-lived resting cells whereas the majority of effector and memory T cells have a much more rapid turnover. However, some memory T cells appear to divide very infrequently and eventually return to a resting state. The factors controlling the generation and maintenance of memory T cells are discussed.
本文综述了成熟T细胞的寿命。外周T淋巴细胞是一个异质性群体，由幼稚细胞、效应细胞和记忆细胞混合组成。成熟T细胞的再循环池在幼年时期通过幼稚T细胞从胸腺的逐渐释放而形成。在成年人中，成熟T细胞池相对自给自足，来自胸腺的新T细胞输入降至低水平。对T细胞更新的研究表明，大多数外周T细胞可以长时间处于静止状态（啮齿动物为数月，人类为数年）。对分裂细胞与非分裂细胞表型的检查表明，典型的幼稚T细胞是长寿的静止细胞，而大多数效应T细胞和记忆T细胞的更新速度要快得多。然而，一些记忆T细胞似乎很少分裂，最终恢复到静止状态。本文还讨论了控制记忆T细胞产生和维持的因素。
