Margolick J B, Donnenberg A D
Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA.
Semin Immunol. 1997 Dec;9(6):381-8. doi: 10.1006/smim.1997.0096.
Failure of T-cell homeostasis is an important feature of HIV-1 infection. Substantial evidence indicates that T-cell homeostasis is independent of CD4+ and CD8+ subsets, and this may contribute to the decline of CD4+ T cells to low levels in this disease. Moreover, failure of T-cell homeostasis appears to precede the development of clinically-defined AIDS by approximately 1.5 to 2 years and is thus an important milestone in HIV-1 disease progression. We argue that T-cell turnover and depletion of memory cells in HIV-1 infection can be viewed as the reverse of the process by which immune reconstitution occurs after stem cell transplantation, and that changes in the functional level of T-cell memory may be critical to both processes. An understanding of the relationship between T-cell memory and regeneration of lost T cells may help preserve and/or reconstitute immune system homeostasis in HIV-1-infected individuals.
T细胞稳态失衡是HIV-1感染的一个重要特征。大量证据表明，T细胞稳态独立于CD4+和CD8+亚群，这可能是导致该疾病中CD4+ T细胞数量降至低水平的原因之一。此外，T细胞稳态失衡似乎比临床定义的艾滋病发展提前约1.5至2年出现，因此是HIV-1疾病进展中的一个重要里程碑。我们认为，HIV-1感染中T细胞周转和记忆细胞耗竭可被视为干细胞移植后免疫重建过程的反向过程，并且T细胞记忆功能水平的变化可能对这两个过程都至关重要。了解T细胞记忆与丢失T细胞再生之间的关系，可能有助于维持和/或重建HIV-1感染个体的免疫系统稳态。
