Hadimeri H, Almroth G, Cederbrant K, Eneström S, Hultman P, Lindell A
Department of Internal Medicine, Eksjö County Hospital, Sweden.
Scand J Urol Nephrol. 1997 Oct;31(5):481-5. doi: 10.3109/00365599709030647.
Allergic nephropathy associated with quinolone antibiotics has been reported in an increasing number of cases. The mechanism might be a hypersensitivity reaction. Norfloxacin has been incriminated previously as a cause once only, with acute interstitial nephritis (AIN) as the histopathological finding. Ciprofloxacin-associated nephropathy has been reported in 28 cases, with AIN as the main histopathological finding. This report describes a second case of AIN associated with norfloxacin treatment and another ciprofloxacin-associated renal interstitial drug adverse reaction. Clinicians should be aware of quinolone-associated AIN, which is a rare but potentially dangerous renal complication.
越来越多的病例报告了与喹诺酮类抗生素相关的过敏性肾病。其机制可能是超敏反应。诺氟沙星以前仅被认定为一次病因，组织病理学表现为急性间质性肾炎（AIN）。环丙沙星相关肾病已有28例报告，主要组织病理学表现为AIN。本报告描述了第二例与诺氟沙星治疗相关的AIN以及另一例环丙沙星相关的肾间质药物不良反应。临床医生应了解喹诺酮相关的AIN，这是一种罕见但潜在危险的肾脏并发症。
