Stradling J, Davies R J
Osler Chest Unit, Churchill Hospital, Oxford, U.K.
Sleep. 1997 Sep;20(9):789-93. doi: 10.1093/sleep/20.9.789a.
It is unarguable that obstructive sleep apnea (OSA) causes pulsatile hypertension during sleep, but whether there is significant carryover of hypertension into waking hours is far from clear. It is perhaps more useful to consider whether OSA is related to the consequences of hypertension (e.g. stroke), since both nocturnal and daytime hypertension could be responsible for these. Furthermore, the effects of nasal continuous positive airway pressure (CPAP) on hypertension (or its consequences) must be assessed by randomized controlled studies, in exactly the same way as trials on hypotensive drugs would be carried out, before treatment is prescribed for OSA in the absence of any daytime symptoms.
无可争议的是，阻塞性睡眠呼吸暂停（OSA）会在睡眠期间导致搏动性高血压，但高血压是否会显著延续至清醒时间，这一点还远不清楚。考虑OSA是否与高血压的后果（如中风）相关可能更有意义，因为夜间和白天的高血压都可能导致这些后果。此外，在没有任何日间症状的情况下为OSA开治疗处方之前，必须通过随机对照研究来评估鼻持续气道正压通气（CPAP）对高血压（或其后果）的影响，就如同对降压药物进行试验那样。
