Silverberg D S, Oksenberg A
Department of Nephrology, Tel Aviv Medical Center, Israel.
Sleep. 1997 Sep;20(9):794-806.
The epidemiological, clinical, hereditary, biochemical, hematological, and physiological characteristics of essential hypertension (EH) and obstructive sleep apnea (OSA) are reviewed here. This extensive review shows that essential hypertension and sleep-disordered breathing--independently of whether it is OSA syndrome or upper airway resistance syndrome--share strikingly similar characteristics. The accumulated data obtained by many different researchers support the hypothesis that EH is mainly due to increased upper airway resistance during sleep. If this hypothesis is correct, treating disorders that cause increased upper airway resistance, particularly during sleep, would be an important part of the treatment of essential hypertension.
本文综述了原发性高血压（EH）和阻塞性睡眠呼吸暂停（OSA）的流行病学、临床、遗传、生化、血液学及生理学特征。这一全面综述表明，原发性高血压和睡眠呼吸障碍——无论其为OSA综合征还是上气道阻力综合征——具有显著相似的特征。众多不同研究者积累的数据支持了这样的假说，即原发性高血压主要是由于睡眠期间上气道阻力增加所致。如果这一假说正确，那么治疗导致上气道阻力增加的疾病，尤其是在睡眠期间导致该情况的疾病，将成为原发性高血压治疗的重要组成部分。
