阻塞性睡眠呼吸暂停综合征

Obstructive sleep apnea syndromes.

作者信息

Collop Nancy A

机构信息

Department of Medicine, Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21205, USA.

出版信息

Semin Respir Crit Care Med. 2005 Feb;26(1):13-24. doi: 10.1055/s-2005-864198.

Abstract

Complete or partial collapse of the upper airway during sleep has different effects on the human body ranging from noisy breathing (snoring) to significant cardiovascular sequelae as seen in obstructive sleep apnea (OSA). Snoring is very common in the adult population and has been associated with morbidity in epidemiological studies. A variety of treatments may be used for primary snoring (snoring without symptoms) but none are universally successful. The upper airway resistance syndrome is thought to occur when incomplete obstruction of the upper airway results in frequent disruptions in sleep. Whether it is a true "syndrome" or just one end of the continuum of OSA is unclear. Obstructive sleep apnea causes not only sleep disruption but oxygen desaturation. It has been associated with numerous cardiovascular sequelae, including hypertension (systemic and pulmonary), arrhythmias, and stroke. Nasal continuous positive airway pressure (CPAP) is the current treatment of choice, with lesser alternatives including oral appliances, surgery, and weight loss. Further study on outcomes is required to determine how aggressively to treat these syndromes.

摘要

睡眠期间上呼吸道的完全或部分塌陷对人体有不同影响,从呼吸嘈杂(打鼾)到出现阻塞性睡眠呼吸暂停(OSA)时显著的心血管后遗症。打鼾在成年人群中非常普遍,并且在流行病学研究中已与发病率相关。多种治疗方法可用于原发性打鼾(无症状的打鼾),但没有一种是普遍成功的。当上呼吸道不完全阻塞导致睡眠频繁中断时,就会发生上气道阻力综合征。它是否是一种真正的“综合征”,还是仅仅是阻塞性睡眠呼吸暂停连续体的一端,尚不清楚。阻塞性睡眠呼吸暂停不仅会导致睡眠中断,还会导致氧饱和度下降。它与许多心血管后遗症有关,包括高血压(全身性和肺部)、心律失常和中风。鼻持续气道正压通气(CPAP)是目前的首选治疗方法,其他选择包括口腔矫治器、手术和减肥。需要进一步研究结果,以确定如何积极治疗这些综合征。

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