Canales E S, Garrido J T, Zárate A, Mason M, Soria J
Obstet Gynecol. 1976 Aug;48(2):228-9.
The effect of ergonovine maleate on prolactin secretion and lactation was determined in 10 puerperal women. Serum prolactin concentration measured by radioimmunoassay resulted in 537.2 +/- 45.9 ng/ml (M +/- SE) before the oral administration of 0.6 mg ergonovine maleate, and 89.7 +/- 25.6 ng/ml after 7 days of therapy. The serum prolactin concentration seen in the control group of nonlactating women (562.0 +/- 36.1 and 218.0 +/- 27.3 ng/ml) was significantly greater than (P less than 0.01) that seen in the treated group. In 2 additional patients it was also demonstrated that the simultaneous administration of ergonovine by oral and intravenous routes potentiates the suppressive effect on prolactin secretion. Three of the 10 treated women showed progressive inhibition of lactation. This study shows that ergonovine maleate interferes with prolactin secretion, and may decrease milk production.
在10名产后妇女中测定了马来酸麦角新碱对催乳素分泌和泌乳的影响。通过放射免疫分析法测得，口服0.6毫克马来酸麦角新碱前血清催乳素浓度为537.2±45.9纳克/毫升（均值±标准误），治疗7天后为89.7±25.6纳克/毫升。非泌乳妇女对照组的血清催乳素浓度（562.0±36.1和218.0±27.3纳克/毫升）显著高于（P＜0.01）治疗组。在另外2名患者中还证实，口服和静脉注射同时给予麦角新碱可增强对催乳素分泌的抑制作用。10名接受治疗的妇女中有3名表现出泌乳逐渐受到抑制。本研究表明，马来酸麦角新碱干扰催乳素分泌，并可能减少乳汁分泌。
