Leake R D, Trygstad C W, Oh W
Pediatr Res. 1976 Aug;10(8):759-62. doi: 10.1203/00006450-197608000-00013.
Thirty-eight healthy newborn infants with gestational ages ranging from 25 to 42 weeks were studied at 2 days to 9 weeks postnatal age to evaluate the rate of glomerular maturation after birth. Glomerular function was assessed by a constant infusion method for inulin clearance (Cin). Cin was nearly identical when measured by the traditional clearance method and by the constant infusion technique. The Cin of 22 infants 2-3 days old ranged from 0.6 to 17.9 ml/min and was directly related to gestational age (r = 0.81, P less than 0.001). For 26 infants studied at 1-9 weeks of age, Cin was directly proportional to conceptual (gestational and postnatal) age (r = 0.89, P less than 0.001), and approximated that of infants of similar gestational age studied at 2-3 days of age.
对38名胎龄在25至42周的健康新生儿进行了研究，研究时间为出生后2天至9周，以评估出生后肾小球成熟的速率。通过持续输注法测定菊粉清除率（Cin）来评估肾小球功能。用传统清除法和持续输注技术测量时，Cin几乎相同。22名2 - 3日龄婴儿的Cin范围为0.6至17.9毫升/分钟，且与胎龄直接相关（r = 0.81，P < 0.001）。对于26名在1 - 9周龄时研究的婴儿，Cin与胎龄（胎龄和出生后年龄）成正比（r = 0.89，P < 0.001），并且接近在2 - 3日龄时研究的类似胎龄婴儿的Cin。
