• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

人体口腔气道尺寸的测量及传质特性的计算。

Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage.

作者信息

Cheng K H, Cheng Y S, Yeh H C, Swift D L

机构信息

Department of Environmental Health Sciences, School Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

出版信息

J Biomech Eng. 1997 Nov;119(4):476-82. doi: 10.1115/1.2798296.

DOI:10.1115/1.2798296
PMID:9407288
Abstract

This paper presents measurements of the geometric shape, perimeter, and cross-sectional area of the human oral passage (from oral entrance to midtrachea) and relates them through dimensionless parameters to the depositional mass transfer of ultrafine particles. Studies were performed in two identical replicate oral passage models, one of which was cut orthogonal to the airflow direction into 3 mm elements for measurement, the other used intact for experimental measurements of ultrafine aerosol deposition. Dimensional data were combined with deposition measurements in two sections of the oral passage (the horizontal oral cavity and the vertical laryngeal-tracheal airway) to calculate the dimensionless mass transfer Sherwood number (Sh). Mass transfer theory suggests that Sh should be expressible as a function of the Reynolds number (Re) and the Schmidt number (Sc). For inhalation and exhalation through the oral cavity (O-C), an empirical relationship was obtained for flow rates from 7.5-30.0 1 min-1: Sh = 15.3 Re0.812 Sc-0.986 An empirical relationship was likewise obtained for the laryngeal-tracheal (L-T) region over the same range of flow rates: Sh = 25.9 Re0.861 Sc-1.37 These relationships were compared to heat transfer in the human upper airways through the well-known analogy between heat and mass transfer. The Reynolds number dependence for both the O-C and L-T relationships was in good agreement with that for heat transfer. The mass transfer coefficients were compared to extrathoracic uptake of gases and vapors and showed similar flow rate dependence. For gases and vapors that conform to the zero concentration boundary condition, the empirical relationships are applicable when diffusion coefficients are taken into consideration.

摘要

本文介绍了人类口腔通道(从口腔入口到气管中部)的几何形状、周长和横截面积的测量结果,并通过无量纲参数将它们与超细颗粒的沉积传质联系起来。研究在两个相同的复制口腔通道模型中进行,其中一个垂直于气流方向切成3毫米的单元进行测量,另一个保持完整用于超细气溶胶沉积的实验测量。将尺寸数据与口腔通道两个部分(水平口腔和垂直喉气管气道)的沉积测量结果相结合,以计算无量纲传质舍伍德数(Sh)。传质理论表明,Sh应该可以表示为雷诺数(Re)和施密特数(Sc)的函数。对于通过口腔(O-C)的吸入和呼出,在7.5 - 30.0升/分钟的流速范围内获得了经验关系:Sh = 15.3 Re^0.812 Sc^-0.986。在相同的流速范围内,对于喉气管(L-T)区域也获得了类似的经验关系:Sh = 25.9 Re^0.861 Sc^-1.37。通过众所周知的传热与传质类比,将这些关系与人类上呼吸道的传热进行了比较。O-C和L-T关系的雷诺数依赖性与传热的依赖性吻合良好。将传质系数与气体和蒸气的胸外摄取进行了比较,结果显示出相似的流速依赖性。对于符合零浓度边界条件的气体和蒸气,在考虑扩散系数时,这些经验关系是适用的。

相似文献

1
Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage.人体口腔气道尺寸的测量及传质特性的计算。
J Biomech Eng. 1997 Nov;119(4):476-82. doi: 10.1115/1.2798296.
2
An experimental method for measuring aerosol deposition efficiency in the human oral airway.一种测量人体口腔气道中气溶胶沉积效率的实验方法。
Am Ind Hyg Assoc J. 1997 Mar;58(3):207-13. doi: 10.1080/15428119791012856.
3
Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles.口腔气道几何特征对吸入纳米颗粒扩散沉积的影响。
J Biomech Eng. 2008 Feb;130(1):011008. doi: 10.1115/1.2838039.
4
Transport and uptake of MTBE and ethanol vapors in a human upper airway model.
Inhal Toxicol. 2006 Mar;18(3):169-84. doi: 10.1080/08958370500434172.
5
Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway.微气溶胶在真实和简化口腔气道模型中的传输与沉积
Ann Biomed Eng. 2007 Apr;35(4):560-81. doi: 10.1007/s10439-006-9245-y. Epub 2007 Jan 20.
6
Breathing resistance and ultrafine particle deposition in nasal-laryngeal airways of a newborn, an infant, a child, and an adult.新生儿、婴儿、儿童和成人鼻咽喉气道的呼吸阻力和超细颗粒沉积。
Ann Biomed Eng. 2012 Dec;40(12):2579-95. doi: 10.1007/s10439-012-0603-7. Epub 2012 Jun 3.
7
Effect of electrostatic charge on deposition of uniformly charged monodisperse particles in the nasal extrathoracic airways of an infant.静电荷对婴儿鼻外胸段气道中均匀带电单分散颗粒沉积的影响。
J Aerosol Med Pulm Drug Deliv. 2015 Feb;28(1):30-4. doi: 10.1089/jamp.2013.1118. Epub 2014 Apr 1.
8
Growth of nasal and laryngeal airways in children: implications in breathing and inhaled aerosol dynamics.儿童鼻和喉气道的生长:对呼吸和吸入气溶胶动力学的影响。
Respir Care. 2014 Feb;59(2):263-73. doi: 10.4187/respcare.02568. Epub 2013 Jul 2.
9
Numerical investigation of airflow, heat transfer and particle deposition for oral breathing in a realistic human upper airway model.真实人体上呼吸道模型中口腔呼吸气流、传热及颗粒沉积的数值研究。
J Therm Biol. 2017 Dec;70(Pt A):53-63. doi: 10.1016/j.jtherbio.2017.05.003. Epub 2017 May 18.
10
Numerical investigation of transient transport and deposition of microparticles under unsteady inspiratory flow in human upper airways.人体上呼吸道非定常吸气流动下微粒瞬态输运与沉积的数值研究。
Respir Physiol Neurobiol. 2017 Oct;244:56-72. doi: 10.1016/j.resp.2017.06.005. Epub 2017 Jul 1.

引用本文的文献

1
A Novel Trans-Tracheostomal Retrograde Inhalation Technique Increases Subglottic Drug Deposition Compared to Traditional Trans-Oral Inhalation.与传统经口吸入相比,一种新型经气管造口逆行吸入技术可增加声门下药物沉积。
Pharmaceutics. 2023 Mar 10;15(3):903. doi: 10.3390/pharmaceutics15030903.
2
In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway.口腔气道气溶胶沉积个体间变异性的计算机模拟定量分析
Pharmaceutics. 2023 Jan 3;15(1):160. doi: 10.3390/pharmaceutics15010160.
3
Lower Inspiratory Breathing Depth Enhances Pulmonary Delivery Efficiency of ProAir Sprays.
较低的吸气呼吸深度可提高普米克气雾剂的肺部给药效率。
Pharmaceuticals (Basel). 2022 Jun 3;15(6):706. doi: 10.3390/ph15060706.
4
Effects of chlorine particle concentration on the human airway.氯颗粒浓度对人体气道的影响。
J Nanopart Res. 2022;24(6):105. doi: 10.1007/s11051-022-05493-5. Epub 2022 May 20.
5
Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung.多分散气溶胶在上呼吸道中的输送和沉积。
Int J Environ Res Public Health. 2021 Jun 9;18(12):6239. doi: 10.3390/ijerph18126239.
6
In vitro delivery efficiencies of nebulizers for different breathing patterns.不同呼吸模式下雾化器的体外输送效率。
Biomed Eng Online. 2021 Jun 10;20(1):59. doi: 10.1186/s12938-021-00895-3.
7
SARS COV-2 virus-laden droplets coughed from deep lungs: Numerical quantification in a single-path whole respiratory tract geometry.从深部肺部咳出的携带新冠病毒的飞沫:单路径全呼吸道几何结构中的数值量化
Phys Fluids (1994). 2021 Feb;33(2):023306. doi: 10.1063/5.0040914. Epub 2021 Feb 22.
8
Computational fluid dynamic models as tools to predict aerosol distribution in tracheobronchial airways.计算流体动力学模型作为预测气管支气管气道中气溶胶分布的工具。
Sci Rep. 2021 Jan 13;11(1):1109. doi: 10.1038/s41598-020-80241-0.
9
Evaluation of wearing comfort of dust masks.防尘口罩佩戴舒适性评价
PLoS One. 2020 Aug 20;15(8):e0237848. doi: 10.1371/journal.pone.0237848. eCollection 2020.
10
Numerical simulations of aerosol delivery to the human lung with an idealized laryngeal model, image-based airway model, and automatic meshing algorithm.利用理想化喉部模型、基于图像的气道模型和自动网格划分算法对气溶胶输送至人肺的数值模拟。
Comput Fluids. 2017 Apr 22;148:1-9. doi: 10.1016/j.compfluid.2017.02.008. Epub 2017 Feb 10.