Gałazka-Friedman J, Friedman A
Institute of Physics, Warsaw University of Technology, Poland.
Acta Neurobiol Exp (Wars). 1997;57(3):217-25. doi: 10.55782/ane-1997-1229.
According to the oxidative stress theory iron may play an important role in the pathogenesis of neurodegenerative diseases, as e.g. Parkinson's disease (PD). This review presents the results of studies, obtained by various methods, of iron in substantia nigra (SN)--a cerebral structure which degenerates in PD--and shows controversies concerning the amount of iron, its redox state, and the iron binding compounds. Taking into account all published experimental results, the increase in the concentration of iron in parkinsonian SN vs. control may be estimated as (3 +/- 5)%. The presence of large amounts of divalent iron in post mortem SN can be unequivocally negated. It is, however, still possible that iron is involved in the pathogenesis of PD, as even minor changes in the amount and form of iron may initiate processes leading to cells death.
根据氧化应激理论，铁可能在神经退行性疾病（如帕金森病，PD）的发病机制中起重要作用。本综述展示了通过各种方法对黑质（SN）中铁的研究结果，黑质是一种在帕金森病中会退化的脑结构，同时也揭示了关于铁的含量、氧化还原状态以及铁结合化合物方面存在的争议。综合所有已发表的实验结果，帕金森病患者黑质中铁浓度相对于对照组的增加量估计为（3±5）%。可以明确否定死后黑质中存在大量二价铁这一说法。然而，铁仍有可能参与帕金森病的发病机制，因为即使铁的含量和形式发生微小变化也可能引发导致细胞死亡的过程。
