Sofic E, Riederer P, Heinsen H, Beckmann H, Reynolds G P, Hebenstreit G, Youdim M B
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
J Neural Transm. 1988;74(3):199-205. doi: 10.1007/BF01244786.
Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 225% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder.
在帕金森病患者死后的黑质中发现铁（III）和总铁含量存在显著差异。与年龄匹配的对照组相比，帕金森病患者黑质中的总铁水平增加了176%，铁（III）水平增加了225%。在皮质（布罗德曼21区）、海马体、壳核和苍白球中，铁（III）和总铁水平没有显著差异。因此，帕金森病患者黑质中总铁、铁（III）以及铁（II）/铁（III）比值的变化可能与该疾病的病理生理学和治疗有关。
