Damjanovich J, Berta A, Vezendi L
Department of Ophthalmology, University Medical School of Debrecen, Hungary.
Acta Chir Hung. 1997;36(1-4):67-8.
Between the end of 1986 and the end of October 1996 81 patients suffering from choroidal melanoma were irradiated at the Department of Ophthalmology University Medical School of Debrecen. The irradiations were performed with Ruthenium-106 beta ray emitting scleral plaques (ophthalmic applicators). The radioactive plaques were implanted surgically, fixed by episcleral sutures onto the sclera covering the base of the tumour, and removed by another operation when sufficient time for irradiation had elapsed. For the treatment of tumours in the vicinity of the optic nerve special plaques were used with a notch for the nerve. Precise localisation of the tumours was established by intraoperative ultrasonography and transillumination. The mean follow up period was 3.5 years after the irradiation. Tumour regression was recorded by fluorescein angiography, ultrasonography and fundus photography. In 75 cases (92.5%) the treatment was successful. Additional laser photocoagulation was performed after irradiation in 26 cases. The irradiation by Ruthenium-106 scleral plaques of choroidal melanomas proved to be an effective treatment in cases of small and medium sized choroidal melanomas in our practice and the results are similar to those of the largest radiotherapy centers of Europe.
1986年底至1996年10月底，德布勒森大学医学院眼科对81例脉络膜黑色素瘤患者进行了放射治疗。放射治疗采用发射β射线的钌-106巩膜敷贴器（眼科敷贴器）。放射性敷贴器通过手术植入，用巩膜外缝线固定在覆盖肿瘤底部的巩膜上，在经过足够的照射时间后，通过另一次手术取出。对于视神经附近的肿瘤，使用带有神经切口的特殊敷贴器。通过术中超声检查和透照法对肿瘤进行精确定位。照射后的平均随访期为3.5年。通过荧光素血管造影、超声检查和眼底摄影记录肿瘤消退情况。75例（92.5%）治疗成功。26例在照射后进行了额外的激光光凝治疗。在我们的实践中，钌-106巩膜敷贴器照射脉络膜黑色素瘤对中小型脉络膜黑色素瘤病例证明是一种有效的治疗方法，其结果与欧洲最大的放疗中心相似。
