Roman D D, Kubo S H, Ormaza S, Francis G S, Bank A J, Shumway S J
Department of Physical Medicine, University of Minnesota Hospital and Clinic, USA.
J Clin Exp Neuropsychol. 1997 Oct;19(5):692-7. doi: 10.1080/01688639708403754.
Seventeen patients with severe cardiomyopathy underwent neuropsychological evaluation prior to and at least 1 year after successful heart transplantation. Study candidates were screened, and individuals with a history of stroke, cardiac arrest, or medical and neurological conditions which might affect brain function were excluded. Pre-transplant testing revealed normal intelligence and normal attentional, language, and executive abilities but impaired recent memory. Following heart transplant, memory functioning improved significantly, reaching normal levels. Other cognitive abilities remained unchanged. Results suggest that cardiomyopathy is associated with mesial temporal dysfunction, possibly attributable to inadequate or reduced cerebral blood flow and related hypometabolism. This cerebral dysfunction is potentially reversible following successful transplantation, which restores cardiac output and cerebrovascular perfusion.
17名患有严重心肌病的患者在成功进行心脏移植之前和之后至少1年接受了神经心理学评估。对研究对象进行了筛查，排除了有中风、心脏骤停病史或可能影响脑功能的医学和神经疾病患者。移植前测试显示智力正常，注意力、语言和执行能力正常，但近期记忆力受损。心脏移植后，记忆功能显著改善，达到正常水平。其他认知能力保持不变。结果表明，心肌病与内侧颞叶功能障碍有关，可能归因于脑血流量不足或减少以及相关的代谢减退。成功移植后，这种脑功能障碍可能是可逆的，因为移植可恢复心输出量和脑血管灌注。
