Schulz K P, McKay K E, Newcorn J H, Sharma V, Gabriel S, Halperin J M
Department of Psychology, Graduate School, City University of New York, New York, USA.
Neuropsychopharmacology. 1998 Jan;18(1):10-7. doi: 10.1016/S0893-133X(97)00091-2.
Data in animals and adults indicate that central serotonergic (5-HT) function may be involved in the development of alcohol abuse. Despite this, studies exploring this mechanism in individuals at risk for alcoholism are scant. This study used a fenfluramine (FEN) challenge procedure to investigate the relationship between risk for alcoholism and 5-HT function in 7- to 11-year-old boys with attention-deficit hyperactivity disorder (ADHD). The prolactin (PRL) and cortisol (CORT) responses to FEN were examined in 10 sons of alcoholic fathers (FA+) and 30 sons of nonalcoholic fathers (FA-). The FA+ group had a significantly greater CORT, but not PRL, response to FEN relative to the FA- group. The discrepancy between the CORT and PRL responses may be due to the different mechanisms that underlie their 5-HT stimulated release. This suggests that, among ADHD boys, those at familial risk for alcohol abuse may differ from those who are not at risk in 5-HT function.
动物和成人的数据表明，中枢5-羟色胺能（5-HT）功能可能与酒精滥用的发展有关。尽管如此，在有酒精中毒风险的个体中探索这种机制的研究却很少。本研究采用氟苯丙胺（FEN）激发试验，调查患有注意力缺陷多动障碍（ADHD）的7至11岁男孩的酒精中毒风险与5-HT功能之间的关系。对10名酗酒父亲的儿子（FA+）和30名非酗酒父亲的儿子（FA-）进行了FEN激发试验，检测催乳素（PRL）和皮质醇（CORT）的反应。相对于FA-组，FA+组对FEN的CORT反应显著增强，但PRL反应无显著差异。CORT和PRL反应的差异可能是由于它们受5-HT刺激释放的机制不同。这表明，在患有ADHD的男孩中，有酒精滥用家族风险的人与没有风险的人在5-HT功能上可能存在差异。
