Halperin J M, Sharma V, Siever L J, Schwartz S T, Matier K, Wornell G, Newcorn J H
Department of Psychology, Queens College, Flushing, NY 11367.
Am J Psychiatry. 1994 Feb;151(2):243-8. doi: 10.1176/ajp.151.2.243.
This study was designed to assess central serotonergic (5-HT) function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder.
Prolactin response to a challenge dose of the 5-HT agonist d,l-fenfluramine was assessed in 25 7-11-year-old boys with attention deficit hyperactivity disorder who were divided into aggressive and nonaggressive subgroups. In addition, the subgroups were compared on plasma catecholamine metabolites and platelet 5-HT.
The aggressive group had a significantly greater prolactin response to the fenfluramine challenge than the nonaggressive subgroup. The groups did not differ on peripheral measures of neurotransmitter function.
These data suggest that aggressive and nonaggressive children with attention deficit hyperactivity disorder differ in central 5-HT functioning.
本研究旨在评估患有注意力缺陷多动障碍的攻击性男孩和非攻击性男孩的中枢5-羟色胺能（5-HT）功能。
对25名7至11岁患有注意力缺陷多动障碍的男孩进行了研究，这些男孩被分为攻击性亚组和非攻击性亚组，评估了他们对5-HT激动剂d，l-芬氟拉明激发剂量的催乳素反应。此外，还对这两个亚组的血浆儿茶酚胺代谢产物和血小板5-HT进行了比较。
与非攻击性亚组相比，攻击性组对芬氟拉明激发的催乳素反应明显更大。两组在神经递质功能的外周指标上没有差异。
这些数据表明，患有注意力缺陷多动障碍的攻击性儿童和非攻击性儿童在中枢5-HT功能上存在差异。
