Sadeghipour F, Veuthey J L
Laboratoire de Chimie Analytique Pharmaceutique, Université de Genève, Switzerland.
J Chromatogr A. 1997 Nov 7;787(1-2):137-43. doi: 10.1016/s0021-9673(97)00817-0.
A rapid, sensitive and selective liquid chromatographic method with fluorimetric detection was developed for the separation and quantification of four methylenedioxylated amphetamines without interference of other drugs of abuse and common substances found in illicit tablets. The method was validated by examining linearity, precision and accuracy as well as detection and quantification limits. Methylenedioxylated amphetamines were quantified in eight tablets from illicit drug seizures and results were quantitatively compared to HPLC-UV analyses. To demonstrate the better sensitivity of the fluorimetric detection, methylenedioxylated amphetamines were analyzed in serum after a liquid-liquid extraction procedure and results were also compared to HPLC-UV analyses.
建立了一种快速、灵敏且选择性好的液相色谱荧光检测方法，用于分离和定量四种亚甲二氧基苯丙胺，不受其他滥用药物和非法片剂中常见物质的干扰。通过考察线性、精密度、准确度以及检测限和定量限对该方法进行了验证。对非法缉获的八片药片中的亚甲二氧基苯丙胺进行了定量，并将结果与高效液相色谱 - 紫外分析进行了定量比较。为了证明荧光检测具有更好的灵敏度，在液 - 液萃取后对血清中的亚甲二氧基苯丙胺进行了分析，结果也与高效液相色谱 - 紫外分析进行了比较。
