Patrono C, FitzGerald G A
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia 19104-6100, USA.
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2309-15. doi: 10.1161/01.atv.17.11.2309.
Isoprostanes are emerging as a new class of biologically active products of arachidonic acid metabolism of potential relevance to human vascular disease. Their formation in vivo seems to reflect primarily, if not exclusively, a nonenzymatic process of lipid peroxidation. Enhanced urinary excretion of 8-iso-PGF2 alpha has been described in association with cardiac reperfusion injury and with cardiovascular risk factors, including cigarette smoking, diabetes mellitus, and hypercholesterolemia. Besides providing a likely noninvasive index of lipid peroxidation in these settings, measurements of specific F2 isoprostanes in urine may provide a sensitive biochemical end point for dose-finding studies of natural and synthetic inhibitors of lipid peroxidation. Although the biological effects of 8-iso-PGF2 alpha in vitro suggest that it and other isoeicosanoids may modulate the functional consequences of lipid peroxidation, evidence that this is likely in vivo remains inadequate at this time.
异前列腺素正作为一类新的生物活性产物崭露头角，它是花生四烯酸代谢的产物，可能与人类血管疾病相关。它们在体内的形成似乎主要（如果不是唯一的话）反映了脂质过氧化的非酶过程。与心脏再灌注损伤以及包括吸烟、糖尿病和高胆固醇血症在内的心血管危险因素相关的情况中，已发现尿中8-异前列腺素F2α排泄增加。除了在这些情况下提供脂质过氧化可能的非侵入性指标外，尿液中特定F2异前列腺素的测量可为脂质过氧化天然和合成抑制剂的剂量研究提供一个敏感的生化终点。尽管8-异前列腺素F2α在体外的生物学效应表明它和其他异二十碳烷酸可能调节脂质过氧化的功能后果，但目前关于这在体内可能发生的证据仍然不足。
