Kessler C, Spitzer C, Stauske D, Mende S, Stadlmüller J, Walther R, Rettig R
Department of Neurology, Ernst-Moritz-Arndt-University, Greifswald, Germany.
Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2880-4. doi: 10.1161/01.atv.17.11.2880.
The relationship between the apolipoprotein E (apoE) and beta-fibrinogen G/A-455 polymorphisms and cerebrovascular disease (CVD) was examined in the present study. We compared 227 patients with the subtypes of CVD (large-vessel disease, lacunar stroke, cardiac embolism, or undetermined pathomechanisms) with 225 control subjects. The occurrence of apoE isoforms (E2, E3, and E4) and the beta-fibrinogen G/A-455 genotype was determined in these individuals. No differences in apoE polymorphisms or allele frequencies between the CVD patients and control subjects were found. However, analysis of apoE genotypes as a function of stroke subtype revealed that the apoE4 allele was significantly more common in those patients with macroangiopathy-associated CVD. The only CVD risk factor that distinguished patients with the E4 allele from those with other apoE genotypes was elevated cholesterol. No association between the beta-fibrinogen G/A-455 polymorphism and CVD was found. However, homozygosity for the A allele was more common in patients with CVD resulting from large-vessel disease. These data demonstrate that the apoE4 allele and the AA genotype of the beta-fibrinogen G/A-455 polymorphism occur significantly more frequently in patients with CVD resulting from stenosis of large, brain-supplying vessels. Such genetic analyses may further our understanding of the etiology of cerebrovascular disease.
本研究探讨了载脂蛋白E（apoE）和β-纤维蛋白原G/A-455多态性与脑血管疾病（CVD）之间的关系。我们将227例患有CVD亚型（大血管疾病、腔隙性脑梗死、心源性栓塞或病因不明）的患者与225例对照者进行了比较。测定了这些个体中apoE异构体（E2、E3和E4）的出现情况以及β-纤维蛋白原G/A-455基因型。未发现CVD患者与对照者之间apoE多态性或等位基因频率存在差异。然而，对apoE基因型作为卒中亚型函数的分析显示，apoE4等位基因在患有大血管病变相关CVD的患者中显著更常见。将携带E4等位基因的患者与携带其他apoE基因型的患者区分开来的唯一CVD危险因素是胆固醇升高。未发现β-纤维蛋白原G/A-455多态性与CVD之间存在关联。然而，A等位基因纯合子在大血管疾病导致的CVD患者中更为常见。这些数据表明，apoE4等位基因和β-纤维蛋白原G/A-455多态性的AA基因型在由大脑供血大血管狭窄导致的CVD患者中出现的频率显著更高。此类基因分析可能会加深我们对脑血管疾病病因的理解。
