Marin D B, Breuer B, Marin M L, Silverman J, Schmeidler J, Greenberg D, Flynn S, Mare M, Lantz M, Libow L, Neufeld R, Altstiel L, Davis K L, Mohs R C
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
Atherosclerosis. 1998 Sep;140(1):173-80. doi: 10.1016/s0021-9150(98)00105-1.
The purpose of this study was to concurrently assess the relationship of Apolipoprotein E (APOE) with both dementias and vascular illnesses in the very old. Nine hundred and fifty nine subjects (mean age 85 years) in a long-term care facility were genotyped and cognitively tested with the Mini Mental State Exam. All subjects were studied for the relationship of APOE with atherosclerotic heart disease, hypertension, or stroke without concomitant dementia. Four hundred fifty individuals met criteria for inclusion into one of the following groups: Alzheimer's disease (n = 318), vascular dementia (n = 49), or not demented controls (n = 83) and were investigated for the relationship between APOE and these diagnostic categories. APOE epsilon4 was not associated with atherosclerotic heart disease, hypertension, or stroke without concomitant dementia. The APOE epsilon3 allele was more common in men with atherosclerotic heart disease. In contrast, the APOE epsilon4 allele was more common in patients with Alzheimer's disease (22%) and vascular dementia (26%) than in not demented controls (7%). APOE epsilon4 is associated with dementias in the very old, whereas its relationship with either peripheral or central nervous system vascular disease without dementia is not as robust.
本研究的目的是同时评估载脂蛋白E（APOE）与高龄人群中痴呆症和血管疾病之间的关系。对一家长期护理机构中的959名受试者（平均年龄85岁）进行基因分型，并使用简易精神状态检查表进行认知测试。研究了所有受试者中APOE与动脉粥样硬化性心脏病、高血压或无并发痴呆症的中风之间的关系。450名个体符合纳入以下组之一的标准：阿尔茨海默病（n = 318）、血管性痴呆（n = 49）或非痴呆对照组（n = 83），并对APOE与这些诊断类别之间的关系进行了研究。APOE ε4与无并发痴呆症的动脉粥样硬化性心脏病、高血压或中风无关。APOE ε3等位基因在患有动脉粥样硬化性心脏病的男性中更为常见。相比之下，APOE ε4等位基因在阿尔茨海默病患者（22%）和血管性痴呆患者（26%）中比在非痴呆对照组（7%）中更为常见。APOE ε4与高龄人群中的痴呆症有关，而其与无痴呆症的外周或中枢神经系统血管疾病的关系则不那么密切。
