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Asbestos, the mesothelial cell and malignancy: a matter of life or death.

作者信息

Broaddus V C

出版信息

Am J Respir Cell Mol Biol. 1997 Dec;17(6):657-9. doi: 10.1165/ajrcmb.17.6.f141.

DOI:10.1165/ajrcmb.17.6.f141
PMID:9409552
Abstract
摘要

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Effects of asbestos on initiation of DNA damage, induction of DNA-strand breaks, P53-expression and apoptosis in primary, SV40-transformed and malignant human mesothelial cells.石棉对原代、SV40转化及恶性人胸膜间皮细胞DNA损伤起始、DNA链断裂诱导、P53表达和细胞凋亡的影响。
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Spontaneous p53 mutation in murine mesothelial cells: increased sensitivity to DNA damage induced by asbestos and ionizing radiation.小鼠间皮细胞中的自发性p53突变:对石棉和电离辐射诱导的DNA损伤敏感性增加。
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Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity.人类间皮细胞对猿猴病毒40介导的转化和石棉协同致癌作用异常敏感。
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