Curtis P J, Fender H R, Rayford P L, Thompson J C
Surgery. 1976 Aug;80(2):259-65.
We have investigated the roles of the liver and the kidney in the catabolism of secretin, using a specific and sensitive radioimmunoassay. Dogs were prepared with sampling catheters in the aorta, hepatic vein, portal vein, and renal vein and with electromagnetic flow probes on the portal vein, hepatic artery, and renal artery. Secretin levels in the vessels entering and leaving the liver and kidney were determined by radioimmunoassay and the total mass of secretin [concentration (picograms per milliliter) X plasma flow rate (milliliter per minute)] was calculated during an intravenous infusion of exogenous secretin and during release of endogenous secretin by acidification of the proximal intestine. The total masses of secretin entering and leaving the liver were the same during secretin infusion and during the release of endogenous secretin. Under conditions of elevation of plasma secretin, however, the kidney extracted 30 percent of arterial secretin during secretin infusion and 45 percent during release of endogenous secretin. Clearly the kidney is a major site of secretin catabolism.
我们使用一种特异性且灵敏的放射免疫分析法，研究了肝脏和肾脏在促胰液素分解代谢中的作用。给狗制备了用于在主动脉、肝静脉、门静脉和肾静脉采样的导管，并在门静脉、肝动脉和肾动脉上安装了电磁血流探头。通过放射免疫分析法测定进出肝脏和肾脏的血管中的促胰液素水平，并在静脉输注外源性促胰液素期间以及通过酸化近端肠道释放内源性促胰液素期间，计算促胰液素的总质量[浓度（皮克/毫升）×血浆流速（毫升/分钟）]。在促胰液素输注期间和内源性促胰液素释放期间，进出肝脏的促胰液素总质量相同。然而，在血浆促胰液素升高的情况下，在促胰液素输注期间肾脏提取了30%的动脉促胰液素，在内源性促胰液素释放期间提取了45%。显然，肾脏是促胰液素分解代谢的主要部位。
