Coronato S
Cátedra de Patología II, Facultad de Medicina, Universidad Nacional de La Plata, Argentina.
Rev Argent Microbiol. 1997 Jul-Sep;29(3):157-66.
AIDS is a complex illness due to HIV type 1 and 2 infection. It is characterized by an important immunodeficiency mainly caused by depletion of CD4+ T lymphocytes. The reasons for this depletion have not been sufficiently clarified yet. In 1986, Shy Ching Lo astonished the scientific community with reported evidence concerning the direct role played by mycoplasma in the etiopathology of AIDS. Since then, different theories have pointed to mycoplasma as cofactors, commensals or opportunistic agents. Although in vivo and in vitro experiments are controversial they suggest a possible mechanism that would explain the synergism between both agents: the mycoplasma belonging to normal intestinal flora could move to urethra, oropharynx or blood due to high risk sexual practice. There it would proliferate favoured by early immunological disorders related to HIV. It has been speculated that several microorganisms including mycoplasma, acting as superantigens, could induce a chronic CD4+ and CD8+ T lymphocytes activation resulting in apoptosis of the infected lymphocytes. The release of cytokines induced by mycoplasma could influence the progression of the disease.
艾滋病是一种由1型和2型人类免疫缺陷病毒（HIV）感染引起的复杂疾病。其特征是主要由CD4 + T淋巴细胞耗竭导致的严重免疫缺陷。这种耗竭的原因尚未得到充分阐明。1986年，罗时清（音译）报告的有关支原体在艾滋病病因病理学中直接作用的证据震惊了科学界。从那时起，不同的理论指出支原体是辅助因子、共生菌或机会性病原体。尽管体内和体外实验存在争议，但它们提示了一种可能解释两种病原体之间协同作用的机制：由于高危性行为，属于正常肠道菌群的支原体可能转移至尿道、口咽或血液中。在那里，它会因与HIV相关的早期免疫紊乱而增殖。据推测，包括支原体在内的几种微生物作为超抗原，可诱导慢性CD4 +和CD8 + T淋巴细胞活化，导致受感染淋巴细胞凋亡。支原体诱导的细胞因子释放可能影响疾病的进展。
