Lo S C, Tsai S, Benish J R, Shih J W, Wear D J, Wong D M
Department of Infections and Parasitic Diseases Pathology, Armed Forces Institute of Pathology, Washington, DC 20306.
Science. 1991 Mar 1;251(4997):1074-6. doi: 10.1126/science.1705362.
Coinfection with Mycoplasma fermentans (incognitus strain) enhances the ability of human immunodeficiency virus type-1 (HIV-1) to induce cytopathic effects on human T lymphocytes in vitro. Syncytium formation of HIV-infected T cells was essentially eliminated in the presence of M. fermentans (incognitus strain), despite prominent cell death. However, replication and production of HIV-1 particles continued during the coinfection. Furthermore, the supernatant from cultures coinfected with HIV-1 and the mycoplasma contained a factor that inhibited the standard reverse transcriptase enzyme assay. The modification of the biological properties of HIV-1 by coinfection with mycoplasma may be involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS).
与发酵支原体（未知菌株）的合并感染增强了1型人类免疫缺陷病毒（HIV-1）在体外对人T淋巴细胞诱导细胞病变效应的能力。在存在发酵支原体（未知菌株）的情况下，HIV感染的T细胞的合胞体形成基本消除，尽管细胞死亡显著。然而，在合并感染期间，HIV-1颗粒的复制和产生仍在继续。此外，与HIV-1和支原体合并感染的培养物的上清液中含有一种抑制标准逆转录酶酶活性测定的因子。与支原体的合并感染对HIV-1生物学特性的改变可能与获得性免疫缺陷综合征（AIDS）的发病机制有关。
