Lévy P, Wuyam B, Pépin J L, Reutenauer H, Payen J F
Laboratoire de Physiologie, P.R.E.T.A., UJF, Grenoble.
Rev Mal Respir. 1997 Jun;14(3):183-91.
31P magnetic resonance spectroscopy (31P MRS) is a non-invasive method to evaluate high energy compounds [adenosine triphosphate (ATP), phosphocreatin (PCr), inorganic phosphates (Pi)] and intracellular pH (pHi) of skeletal muscle during exercise and recovery. It is a clinically applicable method of investigation for severe COPD patients with respiratory failure since exercise is limited to a single group of muscle (calf). Pronounced alterations of muscular metabolism have been shown in these patients: (1) reduced aerobic capacity (as reflected by the ratio of Pi/PCr as a function of power and changes in recovery kinetics of PCr after exercise and (2) increased anaerobic metabolism (reflected by a decrease in intracellular pH). Four different studies reveal similar abnormalities. Acute oxygen administration partially improves these parameters, suggesting that other factors in addition to hypoxaemia may contribute to the metabolic impairment. The effect of increased physical activity on these abnormalities deserve further investigations.
31P磁共振波谱（31P MRS）是一种非侵入性方法，用于评估运动及恢复过程中骨骼肌的高能化合物[三磷酸腺苷（ATP）、磷酸肌酸（PCr）、无机磷酸盐（Pi）]和细胞内pH值（pHi）。对于患有呼吸衰竭的重度慢性阻塞性肺疾病（COPD）患者而言，这是一种临床适用的检查方法，因为运动仅限于一组肌肉（小腿）。这些患者已出现明显的肌肉代谢改变：（1）有氧能力降低（以Pi/PCr比值作为功率的函数以及运动后PCr恢复动力学的变化来反映），以及（2）无氧代谢增加（以细胞内pH值降低来反映）。四项不同的研究揭示了类似的异常情况。急性吸氧可部分改善这些参数，这表明除低氧血症外，其他因素可能也会导致代谢障碍。增加体力活动对这些异常情况的影响值得进一步研究。
